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Furthermore, a new orally bioavailable GLP-1RA, oral hypoglycemic peptide 2 (OHP2), can confer protective effects on diabetic cardiomyopathy through rescuing cardiac lipotoxicity by inhibiting Rho (the small GTPase) kinase (ROCK)/PPAR pathway [89, 90] (Figure 1)

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However, there have been very few serious side effects found, and these medications are considered safe for both short-term and long-term use

In certain cases, healthcare providers may recommend microdosing GLP-1 drugs as part of a personalized treatment plan, particularly for patients with underlying gastrointestinal issues