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Boosted Energy Levels As patients lose weight and stabilize their blood sugar levels, they often report increased energy and improved mood

The FDA-approved Wegovy label, for example, describes semaglutide as a GLP-1 receptor agonist used with reduced calories and increased physical activity for long-term weight reduction in certain adults and adolescents, and for reducing risk of major cardiovascular events in certain adults with cardiovascular disease and overweight or obesity

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The bidirectional effects of NMDA receptor antagonism on feeding could potentially diminish the weight-lowering efficacy of systemic exposure to NMDA receptor antagonists