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However, due to its moderate cholesterol-lowering effect, QT interval prolongation, and insufficient clinical evidence for cardioprotective effects, probucol has not achieved widespread clinical adoption

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To investigate mechanisms underlying FTLD-GRN, single-cell transcriptomics in the thalamus and frontal cortex of Grn / mice and FTLD-GRN patients identified a conserved astrocytic pathology marked by upregulation of GJA1, AQP4 , and Apoe , and downregulation of the glutamate transporter SLC1A2