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In addition to treating the cardiac stresses that occur with obesity and associated morbidities, such as OSA, additional cardiovascular benefits of GLP-1s are thought to be mediated by their action on vascular smooth muscle cells and endothelial cells

The highest concentration of glutathione is found in the liver, where it offers antioxidant support for liver tissue protection and p450 phase II conjugation pathways, a possible source of reactive oxygen species

Clinical efficacy Efficacy and safety trials: SUSTAIN 17 The global program of clinical trial SUSTAIN (Semaglutide unabated Sustainability in Treatment of Type 2 Diabetes) included a series of Phase IIIA RCTs (SUSTAIN 15), designed to evaluate the efficacy and safety of semaglutide SC administered subcutaneously once a week in a range of people with T2DM, from those who have not received drugs to those who received oral antidiabetic drugs and/or insulin